Hot Melt Extrusion Services for Drug Product Development

Advance challenging drug product programs with development support designed to move from formulation strategy through scalable manufacturing and regulatory readiness. DRK Research Solutions combines CDMO expertise, analytical development, technology transfer, and commercial-batch planning to help pharmaceutical and biopharmaceutical teams make informed decisions, reduce handoffs, and progress products toward regulated markets with scientific and operational focus.

Scientist reviewing pharmaceutical formulation samples

Our Hot Melt Extrusion Services

Integrated development, analytical, transfer, manufacturing, and regulatory support for complex drug product programs.

Formulation Development

Develop and optimize lab-scale formulation strategies with scientific precision and regulatory foresight, establishing a robust foundation for drug product development and subsequent scale-up decisions.

Analytical Development

Create validated analytical methods that support product quality, safety, and regulatory compliance throughout formulation development, manufacturing transfer, and dossier preparation activities.

Technology Transfer

Coordinate transfer of development knowledge and processes to manufacturing facilities or CDMO partners, supporting consistency, scalability, and clear technical alignment across teams.

Integrated Development Support

Build a Stronger Development Pathway

Drug product development requires coordinated scientific, operational, and regulatory planning. DRK Research Solutions supports programs with lab-scale formulation development, analytical method development, technology transfer, and exhibit or commercial batch manufacturing capabilities. For hot melt extrusion projects, the team can assess development requirements within the broader product strategy, helping sponsors align formulation work, scalability considerations, documentation, and market-readiness goals through an end-to-end CDMO approach.

Pharmaceutical team reviewing drug product development data
The DRK Difference

Why Choose DRK Research Solutions?

A globally connected partner for coordinated pharmaceutical development and market-readiness support.

Global Network

Worldwide operational reach combines broad pharmaceutical capability with localized insight across key international markets.

Integrated Expertise

CRO and CDMO capabilities help align development activities from formulation strategy through commercial product launch.

Timely Delivery

Focused project coordination supports accelerated innovation and shorter development timelines for sponsor programs.

Patient Focus

Every program reflects a commitment to expanding access to innovative therapies, including underserved populations.

Meet the DRK Leadership

Multidisciplinary leaders guiding global pharmaceutical development programs.

Portrait of Dr. Shahab Q. Khokhar, Executive Director at DRK Research Solutions

Dr. Shahab Q. Khokhar

Executive Director

Dr. Shahab Q. Khokhar serves as Executive Director at DRK Research Solutions SA, bringing strategic leadership and deep pharmaceutical expertise to the organization's global operations. With a career rooted in clinical research and pharmaceutical development, Dr. Khokhar has been instrumental in shaping DRK's growth from a Patient Advocacy Organization into a full-service CRO and CDMO. He provides executive oversight across multi-regional clinical trials, regulatory compliance, and business strategy, ensuring the company upholds the highest GxP and ethical standards. His vision drives DRK's commitment to expanding access to innovative therapies, particularly for underserved populations across LMICs in Europe, the Middle East, Asia, Africa, and the Americas.

Portrait of Azka Wase, Head of Business Development at DRK Research Solutions

Azka Wase

Head Of Business Development

Azka Wase is the Head of Business Development at DRK Research Solutions SA, responsible for driving strategic partnerships and expanding the company's global client base across the pharmaceutical and biopharmaceutical sectors. With a strong foundation in life sciences and commercial strategy, Azka leads efforts to connect sponsors, research institutions, and healthcare partners with DRK's end-to-end CRO and CDMO capabilities. Her work spans DRK's operational regions, including Europe, the Middle East, Asia, Africa, and the Americas. Azka is committed to building meaningful, long-term collaborations that accelerate drug development timelines and ultimately improve patient access to innovative treatments worldwide.

Portrait of Vipan Dhall, Ph.D., Chief Scientific Officer at DRK Research Solutions

Vipan Dhall, Ph.D.

Chief Scientific Officer

Vipan Dhall, Ph.D., serves as Chief Scientific Officer at DRK Research Solutions SA, leading the company's scientific strategy and innovation agenda. With advanced expertise in pharmaceutical sciences, Dr. Dhall oversees the scientific direction of clinical development programs and CDMO services, including generics and hybrid product development for regulated markets. He plays a central role in ensuring that DRK's research methodologies meet the highest standards of scientific rigor and regulatory compliance. Dr. Dhall is passionate about leveraging cutting-edge science and technology to bring therapies to patients faster, consistent with DRK's core value of innovation with purpose and its mission to enhance global healthcare access.

Portrait of Dr. Isabel Potani, PhD, Clinical Trials Implementation Specialist at DRK Research Solutions

Dr. Isabel Potani, PhD

Clinical Trials Implementation Specialist

Dr. Isabel Potani, PhD, is a Clinical Trials Implementation Specialist at DRK Research Solutions SA, bringing specialized expertise in the design, coordination, and execution of clinical trials across diverse international settings. With a particular focus on multi-regional clinical trials, Dr. Potani ensures rigorous implementation standards are maintained from site initiation through study completion. Her background and dedication to patient-centric research make her especially effective in trials targeting underserved and LMIC populations. Dr. Potani collaborates closely with global sponsors, site investigators, and regulatory bodies to deliver high-quality clinical data while prioritizing participant safety and study integrity throughout every phase of the trial process.

Portrait of Dr. Zenaida Reynoso-Mojares, Chief Medical Officer at DRK Research Solutions

Dr. Zenaida Reynoso-Mojares

Chief Medical Officer

Dr. Zenaida Reynoso-Mojares serves as Chief Medical Officer at DRK Research Solutions SA, providing senior medical leadership across the company's clinical development portfolio. With extensive experience in clinical medicine and pharmaceutical research, she oversees medical strategy, patient safety, and the medical integrity of DRK's clinical trial programs from Phase II through Phase IV. Dr. Reynoso-Mojares ensures that all clinical activities adhere to the highest GxP, ethical, and regulatory standards across DRK's global operational regions, including Europe, the Middle East, Asia, Africa, and the Americas. Her patient-centric philosophy aligns with DRK's core mission of improving healthcare access for underserved populations worldwide.

Portrait of Dr. Onesmo Mpanju, Regional Head USA & Africa at DRK Research Solutions

Dr. Onesmo Mpanju

Regional Head – USA & Africa

Dr. Onesmo Mpanju is the Regional Head for USA & Africa at DRK Research Solutions SA, leading the company's strategic operations and business development activities across two of its most impactful regions. With a strong background in pharmaceutical research and regional healthcare systems, Dr. Mpanju manages DRK's presence at its Aldie, Virginia office while fostering key relationships with sponsors, research institutions, and healthcare partners across the African continent. His expertise in navigating diverse regulatory environments and his dedication to expanding clinical research capabilities in underserved African markets directly support DRK's mission to enhance global healthcare access, particularly for low- and middle-income country populations.

Portrait of Dr. Zafar Mirza, Senior Strategic Advisor at DRK Research Solutions

Dr. Zafar Mirza

Senior Strategic Advisor

Dr. Zafar Mirza brings distinguished expertise to DRK Research Solutions SA as Senior Strategic Advisor, providing high-level guidance on global health policy, regulatory strategy, and pharmaceutical development. With a career spanning international health organizations and pharmaceutical research, Dr. Mirza offers invaluable insight that helps shape DRK's long-term strategic direction. His advisory role supports the company's mission to bridge global healthcare gaps and improve access to modern treatments, particularly in underserved regions. Dr. Mirza's deep knowledge of global regulatory landscapes and his commitment to equitable healthcare access make him a cornerstone of DRK's leadership team and an essential voice in the company's patient-centric philosophy.

Portrait of Dr. Nigel Whittle, Country Head UK at DRK Research Solutions

Dr. Nigel Whittle

Country Head UK

Dr. Nigel Whittle serves as Country Head UK for DRK Research Solutions SA, overseeing all operations and business activities from the company's Cambridge, United Kingdom office. With extensive experience in the UK pharmaceutical and clinical research landscape, Dr. Whittle manages local stakeholder relationships, regulatory engagements, and business development across the United Kingdom and broader European markets. He ensures that DRK's UK operations maintain the highest standards of compliance and service delivery consistent with the company's global reputation. Dr. Whittle's localized expertise combined with DRK's worldwide capabilities enables seamless delivery of CRO and CDMO services to pharmaceutical and biopharmaceutical clients across Europe.

Portrait of Muhammad Mazree, Regional Head Southeast Asia at DRK Research Solutions

Muhammad Mazree

Regional Head - Southeast Asia

Muhammad Mazree is the Regional Head for Southeast Asia at DRK Research Solutions SA, directing the company's operations and growth strategy from its Shah Alam, Selangor, Malaysia office. With deep knowledge of the Southeast Asian pharmaceutical market, regulatory environment, and clinical research ecosystem, Muhammad manages key regional partnerships and oversees business development activities across this dynamic and rapidly growing market. He ensures that DRK's global CRO and CDMO capabilities are effectively delivered to local pharmaceutical and biopharmaceutical clients while maintaining the company's exacting standards of quality and compliance. His regional leadership is critical to DRK's mission of expanding healthcare access across Asia.

Portrait of Krishnaveni Thanappan, Clinical Data Manager at DRK Research Solutions

Krishnaveni Thanappan

Clinical Data Manager

Krishnaveni Thanappan is a Clinical Data Manager at DRK Research Solutions SA, specializing in the collection, management, and quality assurance of clinical trial data across DRK's global studies. With expertise in data management systems and regulatory-compliant processes, Krishnaveni ensures the integrity, accuracy, and completeness of clinical data from trial initiation through database lock. Her meticulous approach supports DRK's commitment to delivering high-quality evidence that meets the rigorous standards of global regulatory agencies. Krishnaveni works collaboratively with clinical operations, biostatistics, and sponsor teams to maintain seamless data flows, contributing directly to the success of multi-regional clinical trials and the advancement of innovative pharmaceutical therapies.

Portrait of Maha Fareed, Lead PMD & OD at DRK Research Solutions

Maha Fareed

Lead PMD & OD

Maha Fareed serves as Lead Project Management & Organizational Development (PMD & OD) at DRK Research Solutions SA, driving the effective planning, execution, and delivery of the company's complex pharmaceutical and clinical research projects. With a strong background in project management and organizational development, Maha ensures that DRK's cross-functional teams operate with efficiency, cohesion, and strategic alignment across its global offices. She plays a vital role in building internal capabilities and streamlining processes that support timely project delivery—one of DRK's key competitive advantages. Maha's commitment to fostering a diverse, inclusive, and high-performing workplace reflects DRK's core values and its vision for sustainable organizational growth.

Frequently Asked Questions

What is hot melt extrusion in drug product development?

Hot melt extrusion is a continuous processing approach in which ingredients are blended, heated, mixed, and forced through an extruder to create a uniform extrudate. In pharmaceutical development, it is commonly considered for improving dispersion of poorly soluble compounds, producing amorphous solid dispersions, and preparing intermediates for dosage forms such as tablets, capsules, films, or granules. Feasibility depends on the active ingredient, excipients, and product target profile.

When should a sponsor consider hot melt extrusion?

Can hot melt extrusion improve oral bioavailability?

What development support does DRK Research Solutions provide for these programs?

How is hot melt extrusion formulation feasibility assessed?

What analytical work is important for an extrusion-based product?

How does technology transfer support scale-up?

Can DRK Research Solutions support regulatory documentation for drug products?

Need Guidance on Your Program?

Speak with our team about development scope and next steps.

Global Development Partner

Awards and Recognition

Over a Decade trust indicator

Over a Decade

Pharmaceutical development experience since 2012.

100+ professionals trust indicator

100+ Professionals

Multidisciplinary global development expertise.

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Global Network

Operational reach across five regions.

Start Your Drug Product Development Discussion

Share your product objectives and development requirements. Our team will review the scope and identify relevant formulation, analytical, transfer, manufacturing, and regulatory support.

Contact Us Today

For immediate assistance, feel free to give us a direct call at +41 76 797 25 67. You can also send us a quick email at info@drkresearch.com.